Left Atrial Papillary Fibroelastoma and Mediastinal Radiotherapy.

ABSTRACT:

Background

High-dose mediastinal radiotherapy can result in progressive valvular degeneration and secondary malignancy.

Case summary

A 50-year-old woman with prior chest radiotherapy and stem cell transplantation for Hodgkin lymphoma presented with progressive exertional dyspnea. Transthoracic and transesophageal echocardiography revealed severe mitral regurgitation with mitral annular calcification and an incidental finding of a mobile 12 × 8 mm left atrial mass. The patient subsequently underwent mitral valve replacement and resection of the left atrial mass with histologic confirmation of a degenerative, fibrotic mitral valve and a papillary fibroelastoma (PFE).

Discussion

Secondary malignancy can arise after radiotherapy treatment among cancer survivors. This woul

SUBMITTER: How WJ 

PROVIDER: S-EPMC12402372 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature