Neural Representations of Neuropsychiatric Symptoms in Alzheimer's Disease Continuum Using Pathology-Based Functional Connectivity Analysis.

ABSTRACT:

Objectives

Neuropsychiatric symptoms (NPS) in the Alzheimer's disease continuum affect the quality of life for patients and caregivers. Therefore, elucidating the mechanisms of NPS is needed to better understand NPS and enhance patient care. Several studies have investigated them using neuroimaging; however, none have considered the regional coexistence of amyloid-beta and tau pathologies and its association with functional networks. In this study, we aim to identify the neural correlates of NPS considering the molecular and functional levels of neural representation.

Methods

This study included data from amyloid-positive participants in the Alzheimer's Disease Neuroimaging Initiative database with positron emission tomography (PET), functional magnetic resonance imaging, NP

SUBMITTER: Lee T 

PROVIDER: S-EPMC12402403 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature