Assessment of rs1205 and rs1130864 Polymorphisms of C-Reactive Protein Gene (<i>CRP</i>) and Serum CRP Levels in Immune Thrombocytopenia: A Case-Control Study.

ABSTRACT:

Background and aims

Immune thrombocytopenia (ITP) is a rare autoimmune disease of platelet destruction with an unclear mechanism of pathogenesis. A well-known mechanism is the phagocytosis of antibody-coated platelets by the reticuloendothelial system. C-reactive protein (CRP) is a factor in the serum of patients, facilitating this process. We aimed to investigate the relationship between rs1205 (+1846 C>T) and rs1130864 (+1444 G>A) polymorphisms, along with their impact on susceptibility, disease course, treatment outcomes, and laboratory findings in ITP.

Methods

Genomic DNA was extracted from 92 participants (46 patients and 46 healthy controls). Both rs1205 and rs1130864 polymorphisms were genotyped by the tetra-primer amplification refractory mutation system PCR (T-ARMS-

SUBMITTER: Sarbazjoda E 

PROVIDER: S-EPMC12402405 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature