Subjective cognitive decline in major depressive patients is associated with altered entropy and connectivity changes of temporal and insular region.

ABSTRACT: Depressive cognitive impairment is seen in a significant number of patients with depression. However, it remains challenging to differentiate between patients with amnestic (those with subjective cognitive impairment complaints) and non-amnestic major depressive disorder, highlighting the urgent need for additional objective tools to help classify these patients more accurately. We analyzed cognitive state, alterations in regional entropy and functional connectivity measures of the brain between patients with major depression and healthy controls. The depressed cohort was categorized as either "amnestic" or "non-amnestic," depending on self-reported experiences of forgetfulness. The superior temporal region and insula exhibited altered entropy and connectivity measures in individuals with

SUBMITTER: Yulug B 

PROVIDER: S-EPMC12402481 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature