Oral Microbiome and Dental Caries in Kenyan Children and Adolescents Living with HIV.

ABSTRACT:

Objective

This cross-sectional study evaluates the association between the oral microbiome and the presence of untreated dental caries among Kenyan children and adolescents living with HIV (CALHIV).

Methods

We collected 83 oral swab samples from CALHIV receiving medical care at Kenyatta National Hospital. We used the 16S rRNA sequencing technique on oral swab samples to profile bacterial composition. Only CALHIV with results of oral microbiome and dental examinations simultaneously were included in the further analysis. We compared the alpha and beta diversity of the oral microbiome between individuals with and without dental caries. Log-ratio LASSO regression with 2-stage estimation, 10-fold cross-validation, and adjustment for the false discovery rate was applied to select

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12402523 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature