Trends Analysis of Sexually Transmitted Infections Before and After Human Immunodeficiency Virus Pre-exposure Prophylaxis in the United States 2001-2022.

ABSTRACT:

Background

The correlation between human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) usage and sexually transmitted infections (STIs) remains equivocal. Limited studies have investigated national STI trends after introducing PrEP. We aimed to examine STI incidence before and after PrEP introduction and explore correlations with PrEP use in the United States.

Methods

PrEP usage data (2012-2022) were obtained from AIDSVu, and STI data (2001-2022) from the Centers for Disease Control and Prevention's STI Statistics Archive. We used the coefficient of determination to estimate variance in STI rates explained by PrEP usage. We used cross-correlation to identify lagged correlations and segmented linear regression to examine STI trends by demographics before and af

SUBMITTER: Xing Z 

PROVIDER: S-EPMC12402543 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature