Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by motor impairments and intricate pathophysiological mechanisms. Although cerebrospinal fluid (CSF) metabolites are viewed as potential biomarkers, the primarily observational design of the majority of existing studies limits the ability to draw causal conclusions.

Objective

The purpose of this research was to explore the causal link between CSF metabolites and PD by employing two-sample Mendelian randomization (TSMR).

Methods

Data on CSF metabolites were acquired from the two longitudinal cohort studies. Information regarding PD was gathered from the International Parkinson's Disease Genomics Consortium. Instrumental variables (IVs) for 338 CSF metabolites were identified

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12402599 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature