The Mediation of Circulating Inflammatory Proteins in the Causal Pathway From Immune Cells to Delirium.

ABSTRACT:

Objective

Observational research indicates that immune cells, in conjunction with circulating inflammatory proteins, could serve two functions in the development of delirium, despite the fact that the exact mechanisms remain ambiguous. The objective of this research is to identify the specific pathways through which immune cells trigger delirium and to evaluate the possible function of circulating inflammatory proteins as intermediaries.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted using summary-level data from genome-wide association studies, which included 731 immune cells, 91 inflammatory proteins, and their association with delirium. The causal relationships between immune cells, inflammatory proteins, and delirium were systematically assessed

SUBMITTER: Liu T 

PROVIDER: S-EPMC12402607 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature