Circulating TNF-α levels in rheumatoid arthritis: a systematic review and meta-analysis and comparison to TNF-α levels in sepsis.

ABSTRACT:

Background

Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of autoimmune conditions and sepsis. Although anti-TNF-α therapies have demonstrated clinical efficacy in rheumatoid arthritis (RA), there is no established evidence for benefit in patients with sepsis.

Objectives

We sought to quantify circulating TNF-α in patients with RA and compare results to TNF-α levels in sepsis.

Design

We performed a systematic review and meta-analysis of circulating TNF-α in patients with RA. We searched Cochrane Library, Google Scholar, Ovid Embase, Ovid MEDLINE, Scopus, and Web of Science Core Collection databases from inception until May 30, 2023. We included randomized controlled studies and observational reports containing more than ten subjects that reported

SUBMITTER: Scherger S 

PROVIDER: S-EPMC12402614 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature