Activation metrics for structural connectivity recruitment in deep brain stimulation.

ABSTRACT: Comparatively high excitability of myelinated fibres suggests that they represent a major mediator of deep brain stimulation effects. Such effects can be modelled using different levels of abstraction, ranging from simple electric field estimates to complex multicompartment axon models. In this study, we explored three metrics to evaluate axonal activation: electric field magnitudes, electric field projections and pathway activation modelling. Furthermore, in order to account for variability in axonal morphology, these metrics were computed in a probabilistic fashion. To showcase and illustrate their relevance, we retrospectively analysed a dataset of 15 Parkinson's disease patients, who were stimulated in the subthalamic nucleus in bipolar mode. High similarity of activation patterns was

SUBMITTER: Butenko K 

PROVIDER: S-EPMC12402687 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature