Birth weight, incident dementia risk, and PET amyloid burden: The ARIC study.

ABSTRACT:

Introduction

The relationships among birth weight (BW), incident dementia, and amyloid beta (Aβ) are unknown.

Methods

Ten thousand four hundred seventy-six Atherosclerosis Risk in Communities (ARIC) study participants without dementia reported their BW (1996-1998; low [< 5.5 lbs], medium [5.5-9.0 lbs], or high [> 9.0 lbs]), if premature (yes/no), and were followed for incident dementia (N dementia = 2550) through 2019. A subset (N = 312) had florbetapir positron emission tomography (2011-2014). BW was evaluated in association with dementia (Cox proportional hazards) and Aβ (logistic regression), adjusted for demographics, apolipoprotein E ε4, and vascular risk. Effect modification by race was explored.

Results

Neither low BW nor prematurity were associated with dement

SUBMITTER: Emanuel OM 

PROVIDER: S-EPMC12402703 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature