The Open Pediatric Cancer Project.

ABSTRACT:

Background

In 2019, the Open Pediatric Brain Tumor Atlas (OpenPBTA) was created as a global, collaborative open-science initiative to genomically characterize 1,074 pediatric brain tumors and 22 patient-derived cell lines. Here, we present an extension of the OpenPBTA called the Open Pediatric Cancer (OpenPedCan) Project, a harmonized open-source multiomic dataset from 6,112 pediatric cancer patients with 7,096 tumor events across more than 100 histologies. Combined with RNA sequencing (RNA-seq) from the Genotype-Tissue Expression and The Cancer Genome Atlas projects, OpenPedCan contains nearly 48,000 total biospecimens (24,002 tumor and 23,893 normal specimens).

Findings

We utilized Gabriella Miller Kids First workflows to harmonize whole-genome sequencing (WGS), whole exom

SUBMITTER: Geng Z 

PROVIDER: S-EPMC12402770 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature