Elevated serum levels of monocyte chemoattractant protein-1 in 71 patients 3 months after elective cardiac surgery suggest a potential link to persistent inflammation but not an increased propensity for perioperative cerebrovascular events.

ABSTRACT:

Background

Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the transmigration of peripheral monocytes, a central mechanism underlying chronic inflammation. In this study, we investigate postoperative serum kinetics of MCP-1 as a potential contributor to postoperative neurocognitive decline, arteriosclerosis, and the development of organ failures.

Methods

Seventy-one patients undergoing elective cardiac surgery were included in this study. Serum samples were collected preoperatively (t_baseline), and postoperatively at 24 h (t_24h), 7 days (t_7d), and 3 months (t_3m). MCP-1 levels were quantified in conjunction with other inflammatory markers and alarmins. Whole blood samples underwent lipopolysaccharide (LPS) stimul

SUBMITTER: Laudanski K 

PROVIDER: S-EPMC12402827 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature