Macromolecule-Driven Supramolecular Polymerization Induced by Crowding Effects.

ABSTRACT: Macromolecular crowding plays a crucial role in biological systems by regulating dynamic processes, yet its effects in fully synthetic environments remain largely unexplored. Here, we systematically investigate how excluded volume effects influence supramolecular polymerizations in organic media. We employ various discotic supramolecular monomers that assemble sequentially into polymers and kinetically-controlled higher-order aggregates (HOAs) only in the presence of macromolecular crowders. The phase diagram of the supramolecular assemblies reveals a strong dependence on the macromolecule concentration, size, and polarity, which can be tuned to control polymerization. Remarkably, at high crowder concentrations, large condensed and aligned assemblies were observed in dried samples, suggest

SUBMITTER: V D Tol JJB 

PROVIDER: S-EPMC12402893 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature