The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels.

ABSTRACT:

Background/objectives

Hypertensive disorders in pregnancy (HDP) are associated with an increased risk of neonatal complications; however, their effects on neonatal metabolism remain inadequately understood. The aim of this study was to assess the association between HDP and neonatal amino acid and acylcarnitine levels.

Methods

In this retrospective case-control study, 1,228 singleton pregnant women diagnosed with HDP and 1,228 normal singleton pregnant women whose newborns underwent newborn screening for 11 amino acids and 31 acylcarnitines were recruited from January 2021 to December 2023.

Results

After adjusting for potential confounding factors, including gestational age at delivery, birth weight and neonatal sex, nine amino acids exhibited significant differences

SUBMITTER: Xu S 

PROVIDER: S-EPMC12402939 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature