Helicobacter pylori Screening After Acute Myocardial Infarction: The Cluster Randomized Crossover HELP-MI SWEDEHEART Trial.

ABSTRACT:

Importance

Upper gastrointestinal bleeding is common after myocardial infarction.

Objective

To determine whether routine screening for Helicobacter pylori infection during hospitalization for myocardial infarction reduces bleeding events and improves clinical outcomes.

Design, setting, and participants

A nationwide, open-label, 2-period, 2-sequence, cluster randomized, crossover clinical trial using a clinical registry for study population definition and data collection merged with national Swedish health data registries. From November 17, 2021, through January 17, 2024, thirty-five Swedish hospitals grouped into 18 clusters were randomized to a sequence of 1 year with routine H pylori screening of all patients with acute myocardial infarction followed by a washout pe

SUBMITTER: Hofmann R 

PROVIDER: S-EPMC12403021 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature