Vulnerability of mitochondrial OXPHOS complexes in the arcuate nucleus of the hypothalamus of Alzheimer's disease.

ABSTRACT: BackgroundWith increasing recognition of the heterogeneity of the etiopathogenesis of Alzheimer's disease (AD), clinical and basic research has accentuated a contribution of hypothalamic dysfunction to the development of this neurodegenerative disorder. The arcuate nucleus of the hypothalamus (ARH) plays a critical role in maintaining metabolic homeostasis through its regulation of energy storage and expenditure. Although the importance of mitochondrial bioenergetics to the fitness of ARH neurons has been documented, the functional status of mitochondrial oxidative phosphorylation (OXPHOS) complexes in ARH neurons has not been comprehensively investigated in AD-related settings.ObjectiveThis study investigated the mitochondrial OXPHOS complex enzyme activity in ARH of AD patients.MethodsWe

SUBMITTER: Tian J 

PROVIDER: S-EPMC12403022 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature