Magnetic nanoparticles tethered with Zn-DPA for the removal of bacteria from red blood cell suspension.

ABSTRACT: Bacterial infections continue to drive the need for more effective and rapid methods for bacterial analysis. To address this, magnetic nanoparticles (MNPs) have emerged as promising tools, especially when their surfaces are modified with bacteria binders. The bis-zinc-dipicolylamine (Zn-DPA) complex is known for its broad affinity to bacteria. We have synthesized MNPs via a thermal decomposition method, encapsulated them in silica, modified their surface with Zn-DPA, and tested their ability to remove bacteria. The MNPs retain their superparamagnetic properties and crystallite structure after being encapsulated. The MNPs coated with silica and Zn-DPA effectively bind and remove both Gram-positive and Gram-negative bacteria from bacterial suspensions in both PBS buffer and red blood

SUBMITTER: Okonkwo TP 

PROVIDER: S-EPMC12403053 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature