Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.

ABSTRACT: Functional connectivity (FC), a statistical correlation of pair-wise brain signals from resting-state (RS) functional MRI (fMRI), is a widely used concept for mapping large-scale functional networks in both humans and animals. However, its underlying causal mechanism remains poorly understood, particularly for strong interhemispheric connectivity (e.g., homotopic connections) consistently observed in FC. In this study, we investigated the neural basis of RS FC in mice using fMRI with anatomically defined patterned optogenetic activation and inhibition of excitatory neurons in six cortical regions. Unlike commonly used optogenetic activation, optogenetic silencing suppresses spontaneous neural activity in a localized region, reducing RS synaptic inputs to downstream networked areas. Consequ

SUBMITTER: Moon HS 

PROVIDER: S-EPMC12403092 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature