Beyond total depressive symptoms: Differential associations between depressive domains, HIV status and disease characteristics.

ABSTRACT:

Background

People with HIV (PWH) are at two times greater risk for major depressive disorder (MDD) than people without HIV (PWoH), which manifests in symptoms across cognitive, somatic, affective, apathy, and anhedonia domains that may differentially impact clinical outcomes. However, few studies have examined whether HIV and its characteristics relate to depressive symptom domains.

Methods

This secondary, cross-sectional analysis included 3456 participants enrolled in studies at the UCSD HIV Neurobehavioral Research Program and CHARTER sites between 2000 and 2023 (79 % PWH, 78 % male, Age: M = 47.8). Depressive symptom domains were assessed with the Beck Depression Inventory (BDI-II). Multivariable linear regression models evaluated associations between HIV, HIV disease cha

SUBMITTER: Prescott M 

PROVIDER: S-EPMC12403146 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature