Graphene Oxide-Functionalized Optical Sensor for Label-Free Detection of Breast Cancer Cells.

ABSTRACT: Accurate and noninvasive detection of cancer cells is critical for advancing early stage cancer diagnostics and monitoring tumor progression. While manual enumeration methods, such as hemocytometry, remain in use, they suffer from limited sensitivity and scalability. In this article, we report the first feasibility study demonstrating a graphene oxide (GO)-functionalized long-period fiber grating (LPG) sensor for the label-free detection of MCF-7 human breast cancer cell density via secreted cellular byproducts. The sensing mechanism is based on refractive index (RI) modulation in the culture medium, where the GO overlay serves as a functional interface to enhance light-matter interaction and mode coupling between the LPG device and the external medium. GO nanocoatings were deposited on th

SUBMITTER: Sun J 

PROVIDER: S-EPMC12403181 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature