Dihydrotestosterone regulation of stress-related behaviors in mice exposed to subchronic variable stress.

ABSTRACT: Androgen actions through androgen receptors have been shown to regulate stress-related behaviors. However, the role of androgen receptors in regulating stress-related behaviors under chronic stress conditions are unclear. To assess this, male C57BL/6 J mice were gonadectomized and given either a blank capsule or a capsule containing dihydrotestosterone (DHT), which preferentially binds the androgen receptor. Mice were then subjected to subchronic variable stress (SCVS) or control conditions prior to testing for stress-related behaviors. In the open field test, control DHT-treated mice showed a greater number of center entries when compared to control mice that received a blank capsule, indicating decreased anxiety-like behaviors. In the forced swim test, control mice receiving DHT spent le

SUBMITTER: Rybka KA 

PROVIDER: S-EPMC12403196 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature