Tauopathy strains differentially replicate in vitro in the presence of mutant tau monomer.

ABSTRACT: Tauopathies are a group of neurodegenerative diseases caused by misfolding of the protein tau into a β-sheet rich conformation. By inducing misfolding of additional tau monomers, these pathogenic fibrils replicate and spread progressive disease throughout the brain. While frontotemporal lobar degenerative diseases (FTLDs) - including argyrophilic grain disease, corticobasal degeneration, globular glial tauopathy, and progressive supranuclear palsy - are caused by this same underlying molecular process, each disease is defined by a unique clinical and neuropathological presentation. This phenomenon is explained by the strain hypothesis, which proposes that the conformation tau misfolds into determines which disease a patient will develop. Indeed, robust structural and biological data indica

SUBMITTER: Brown CK 

PROVIDER: S-EPMC12403215 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature