Potential therapeutic role of sex steroids in treating sarcopenia: a network pharmacology and molecular dynamics study.

ABSTRACT:

Background

Sarcopenia, characterized by progressive muscle loss and functional decline in aging, poses significant health challenges. Sex steroids, such as estradiol and testosterone, have potential therapeutic roles in mitigating muscle degeneration. This study explores the molecular mechanisms and targets of sex steroids in the treatment of sarcopenia using network pharmacology, enrichment analysis, machine learning, molecular docking, and molecular dynamics simulations.

Methods

We identified potential anti-sarcopenia targets by analyzing the interaction network between sex steroids and their targets, intersecting these with differentially expressed genes (DEGs) from the GSE1428. Enrichment analysis was conducted to determine the functional relevance of these targets. Gene

SUBMITTER: Cui X 

PROVIDER: S-EPMC12403257 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature