Dataset Information
PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP.
Ontology highlight
ABSTRACT:
SUBMITTER: Ritore-Salazar F
PROVIDER: S-EPMC12403285 | biostudies-literature | 2025 Sep
REPOSITORIES: biostudies-literature
Publications
PKP1 promotes lung cancer by modulating energy metabolism through stabilization of PFKP.
Biomarker research 20250901 1
Lung cancer is the leading cause of cancer-related deaths worldwide, with lung squamous cell carcinoma (LUSC) lacking effective targeted therapies. Recent studies have identified Plakophilin-1 (PKP1) as one of the most differentially overexpressed genes in LUSC. This is particularly intriguing given that PKP1 is primarily known as a desmosomal component involved in cell adhesion, typically regarded as a tumor suppressor. To elucidate its biological role, we performed a genome-wide CRISPR knockou ...[more]
