Spatial transcriptomics of retinoblastoma: a visual window on intra-patient heterogeneity.

ABSTRACT:

Background

Retinoblastoma is the most common intraocular malignant tumor in childhood. Although current treatments offer a high survival rate, treatment toxicity, tumor relapse, and treatment resistance require a deeper understanding of the disease mechanisms to develop adapted therapies. Microscopically, this tumor is characterized by different states of differentiation and proliferation, ranging from poorly differentiated to well-differentiated retinoblastoma. Retinocytoma, on the other hand, is a benign non-proliferative tumor. Recent next-generation multi-omics analyses classified retinoblastoma tumors in subtypes 1 or 2, subtype 2 presenting a later age of onset, more genetic alterations, and higher metastatic potential. In parallel, several single-cell transcriptomics studies

SUBMITTER: Moulin AP 

PROVIDER: S-EPMC12403291 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature