A novel SWI/SNF complex promotes triple-negative breast cancer progression.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is the most prevalent and fatal cancer affecting women worldwide. The SWI/SNF complexes exhibit the ability to selectively replace subunits, thereby enabling a wide range of epigenetic functions. As an accessory subunit of this complex, ARID1B is critically involved in modulating chromatin accessibility and transcriptional regulation. Nevertheless, its precise contribution to TNBC pathogenesis remains poorly understood.

Methods

ARID1B expression levels in TNBC were detected using immunofluorescence and real-time quantitative polymerase chain reaction (PCR). To investigate ARID1B's biological functions in TNBC, a series of in vitro assays were conducted, complemented by subcutaneous tumor xenograft models. Mass spectrometry anal

SUBMITTER: Sheng WY 

PROVIDER: S-EPMC12403323 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature