Developing a risk score for B-type natriuretic peptide (BNP) ≥ 100 pg/ml levels: the suita study.

ABSTRACT:

Background

Increased plasma levels of B-type natriuretic peptide (BNP) serve as a biomarker for heart failure (HF). This study aimed to develop a risk score to predict elevated BNP levels using traditional cardiovascular disease (CVD) risk factors.

Methods and results

We analyzed data from 2809 Japanese individuals aged ≥ 40 years from the Suita Study, a population-based prospective cohort. All participants underwent follow-ups involving BNP measurements every two years. Developing BNP levels ≥ 100 pg/mL, a potential indicator of HF requiring treatment, was the outcome. Cox regression was applied to calculate hazard ratios for several CVD risk factors associated with developing BNP levels ≥ 100 pg/mL. Within a median follow-up period of 8 years, 339 participants developed BN

SUBMITTER: Arafa A 

PROVIDER: S-EPMC12403414 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature