In-depth evaluation of XPR1 as a new prognostic indicator for endometrial cancer.

ABSTRACT:

Background

XPR1 is crucial in the development of some tumors, yet its association with endometrial cancer (EC) remains uncertain. We propose that XPR1 exhibits elevated expression in EC and is significantly linked to unfavorable patient outcomes, positioning it as a prospective prognostic biomarker.

Methods

This study investigated XPR1 expression in 554 Uterine Corpus Endometrial Carcinoma(UCEC) cases and 35 normal tissue samples using the The Cancer Genome Atlas(TCGA) database. Western blotting confirmed XPR1 protein presence in EC cell lines (ECC-1) and normal endometrial cells (EEC). The impact of XPR1 on EC cell proliferation and invasion was assessed using EdU proliferation and Transwell invasion assays. A Dot blot assay evaluated m6A methylation of XPR1 in ECC-1 and EE

SUBMITTER: Han X 

PROVIDER: S-EPMC12403429 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature