Serum metabolites as diagnostic biomarkers for preterm labor: a metabolomics-based study.

ABSTRACT:

Background

Preterm labor is a common high-risk condition during pregnancy, but current diagnostic approaches, such as cervical length measurement and uterine contraction monitoring, lack sufficient specificity and sensitivity. This study aims to explore potential biomarkers for threatened preterm labor using untargeted metabolomics, providing novel indicators to improve clinical diagnosis.

Methods

A total of 46 pregnant women from Jiangxi Maternal and Child Health Hospital were retrospectively enrolled in case-control study and divided into a preterm birth group (n = 23) and a control group (n = 23) based on gestational age. Serum metabolic profiles were analyzed using untargeted metabolomics. Differential metabolites were identified via Orthogonal Partial Least Squares Disc

SUBMITTER: Yi Q 

PROVIDER: S-EPMC12403443 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature