Identification of novel Gramicidin S analogs from Aneurinibacillus aneurinilyticus isolated from corn steep liquor with potential antifungal activity.

ABSTRACT: In the existing literature, there is ample information available concerning the analogs constituting linear Gramicidin (Gramicidin A). However, the literature lacks information regarding the microbial production of cyclic Gramicidin S (GR-S) and the study of its analogs' amino acid composition. Thus, in this study, GR-S was produced by Aneurinibacillus aneurinilyticus, isolated from corn steep liquor (CSL) and grown in synthetic or CSL-based medium. The extract was obtained from microbial biomass and underwent analysis with ultra performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) to ascertain the presence and abundance of GR-S clusters, identifying five GR S analogs. Hence, when using a synthetic medium, the dominant cluster com

SUBMITTER: Lvova K 

PROVIDER: S-EPMC12403468 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature