ATE1 promotes breast cancer progression via arginylation-dependent regulation of MAPK-MYC signaling.

ABSTRACT:

Background

Arginyl-tRNA-protein transferase (ATE1) catalyzes N-terminal arginylation, a regulatory protein modification implicated in various cellular processes, including proliferation, apoptosis, and migration. Although ATE1 has context-dependent roles in cancer, its specific function in breast cancer remains unclear. This study investigates the oncogenic role of ATE1 across multiple breast cancer subtypes and its underlying molecular mechanisms.

Methods

ATE1 expression in breast cancer was evaluated using TCGA data and immunoblotting across breast cancer cell lines and normal mammary epithelial cells (HMEC). Functional studies using siRNA- and shRNA-mediated knockdown assessed ATE1's role in cell viability, clonogenic growth, migration, and tumorigenesis in vitro and xeno

SUBMITTER: Nawale L 

PROVIDER: S-EPMC12403503 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature