Correlation of serum pentraxin 3 expression with disease severity and its prognostic value in postmenopausal osteoporosis.

ABSTRACT:

Objective

Pentraxin 3 (PTX3) is an acute-phase protein of the pentraxin family, primarily secreted by immune cells and endothelial cells. This study analyzed its correlation with the severity of postmenopausal osteoporosis (PMOP) and its prognostic value.

Methods

Postmenopausal women (n = 405) were retrospectively selected and arranged into normal bone mineral density (BMD), osteopenia, and PMOP groups. Baseline data and follow-up records were analyzed. Serum PTX3 were quantified, and its correlations with Oswestry Disability Index (ODI), Visual Analogue Scale (VAS) score, BMD, and bone turnover markers (BTMs) were analyzed. The independent risk factors for fractures in PMOP patients were screened. The prediction of PTX3 for fractures was evaluated, and its effects, together

SUBMITTER: Zhang B 

PROVIDER: S-EPMC12403514 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature