Associations between pain experiences and gray matter volume in youth in the adolescent brain cognitive development (ABCD) study.

ABSTRACT: Pain in youth is a growing public health concern. While research suggests pervasive differences in brain morphology with pain in adulthood, this relationship is less studied in adolescence. To address this gap, the present study explored pain-related associations with gray matter volume across 82 brain regions in a community sample of 7712 youth (mean age = 11.96) by comparing structural brain measures between those with (n = 2668; 34.6%) and without (n = 5044; 65.4%) past-month pain and examining associations with a continuous latent pain factor composed of average pain ratings, worst pain ratings, and pain limitations. Results showed no significant morphological differences between groups with and without past-month pain. Among participants reporting pain, average pain limitations were g

SUBMITTER: Bango CI 

PROVIDER: S-EPMC12403542 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature