Transposable element dynamics in glioblastoma stem cells: insights from locus-specific quantification.

ABSTRACT:

Background

Glioblastoma, the most common primary malignant brain tumor, has a median survival of less than two years. This is due in part to a subpopulation of cells called glioblastoma stem cells (GSCs), which drive tumor recurrence. Transposable elements (TEs) are expressed at higher levels in cancer stem cells, enhancing the oncogenic potential and plasticity of cells through changes in gene expression, fusion transcript generation, and genomic rearrangement.

Results

Leveraging a large previously published dataset, we investigated the expression of TEs in bulk RNA sequencing data from 42 GSCs to identify subpopulations defined by their TE expression profile. Using telescope, a locus-specific approach to quantifying TE expression, we identified 858 TE loci that were expres

SUBMITTER: Pizzagalli MD 

PROVIDER: S-EPMC12403600 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature