IITR00803: a benzoxazole-nitrothiophene small molecule with broad-spectrum antibacterial potential.

ABSTRACT: The drug discovery of novel antibacterials is pivotal to combat the ever-growing challenge of antibiotic resistance. The current antibiotics in clinics target the essential pathways in bacteria. However, drug efflux among other resistance mechanisms remains a persistent problem, leading to reduced efficacy of antibiotics. In the present study, we report the discovery of a novel small molecule, IITR00803, with antibacterial properties. IITR00803 demonstrated broad-spectrum antibacterial activity with potent inhibition of enteric pathogens. The small molecule contains a benzoxazole group and a nitrothiophene moiety in its chemical structure. The nitrothiophene-based compounds are prone to efflux by AcrAB-TolC efflux pumps. Despite containing the nitrothiophene group, IITR00803 did not demons

SUBMITTER: Gupta R 

PROVIDER: S-EPMC12403614 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature