Metabolites derived from bacterial isolates of the human skin microbiome inhibit <i>Staphylococcus aureus</i> biofilm formation.

ABSTRACT: The human skin microbiome is a diverse ecosystem that can help prevent infections by producing biomolecules and peptides that inhibit growth and virulence of bacterial pathogens. Staphylococcus aureus is a major human pathogen responsible for diseases that range from acute skin and soft tissue infections to life-threatening septicemia. Its ability to form biofilms is a key virulence factor contributing to its success as a pathogen as well as to its increased antimicrobial resistance. Here, we investigated the ability of bacterial skin commensals to produce molecules that inhibit S. aureus biofilm formation. Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) identified 77 human skin microbiome bacterial isolates from Staphylococcus</

SUBMITTER: Le VH 

PROVIDER: S-EPMC12403628 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature