Inhibitory effects of berberine against <i>Streptococcus mutans</i>: an <i>in vitro</i> insight on its anticaries potential.

ABSTRACT: Dental caries is a prevalent biofilm-related oral infectious disease, in which Streptococcus mutans plays an important role in the pathological process. The discovery of novel agents with inhibitory effects on S. mutans is essential to develop effective strategies against dental caries. Plant extracts are a rich source of novel chemicals for the discovery of more effective antimicrobial agents. Coptis chinensis Franch. is a traditional Chinese herbal medicine with various pharmacological properties. This study aimed to evaluate the antimicrobial activity of berberine (BBR), a bioactive alkaloid isolated from Coptis chinensis Franch., on the biofilm formation of S. mutans and to investigate the relevant mechanism of its action. The study found that BBR inh

SUBMITTER: Zeng C 

PROVIDER: S-EPMC12403641 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature