Cholesterol-rich lipid rafts mediate endocytosis as a common pathway for respiratory syncytial virus entry into different host cells.

ABSTRACT: The entry of respiratory syncytial virus (RSV) into host cells is a multifaceted process involving viral adsorption, interaction of viral glycoproteins with cellular receptors, and utilization of various invasion pathways. Despite these complexities, our understanding of potential common pathways facilitating RSV entry remains limited. In this study, we demonstrate that endocytosis via cholesterol-rich lipid rafts is a common mechanism utilized by various RSV genotypes in different cell types. Specifically, RSV strains A2, B18537, and the currently epidemic ON1 strains all employ this mechanism to gain entry into human cell lines, including HEp-2, A549, and primary human bronchial epithelial cells. Cellular receptors binding to viral fusion glycoprotein were recruited to cholesterol-rich l

SUBMITTER: Zhou A 

PROVIDER: S-EPMC12403703 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature