Impact of fluoride varnish and oral health education on caries increment and dental plaque microbiota among children with early mixed dentition: a three-armed 24-month randomized controlled trial.

ABSTRACT: Dental caries is the most prevalent oral disease globally. A 24-month randomized controlled trial was conducted among 236 children aged between 7 and 8 years (ChiCTR2400084030). They were randomly allocated into three groups and received the following biannual interventions: Group 1: topical fluoride varnish (TFV) using 5% sodium fluoride; Group 2: oral health education (OHE); and Group 3: TFV + OHE. The interventions lasted for 12 months, and a final examination was conducted after 24 months to assess whether the desired effects sustained after the cessation of interventions. After 12-month interventions, when demographic and socioeconomic factors were adjusted, children in Group 1 were more likely to have new caries on their permanent first molars when compared to Group 2 (odds ratio [OR

SUBMITTER: Zeng X 

PROVIDER: S-EPMC12403721 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature