The clinical impact and dissemination of carbapenemase-producing <i>Enterobacter</i>: a genome-based study in China.

ABSTRACT: Carbapenemase-producing Enterobacter (CPEn) has globally emerged to be a severe threat to human health. However, the disease spectrum, impact on affected patients' outcomes, and transmission of CPEn are largely uncharacterized. We performed genome sequencing on a collection of CPEn clinical isolates spanning a six-year period, collating corresponding disease spectrum data and patient prognosis. Among the 128 sequenced CPEn, 2/3 were clinical isolates from a range of infections with bloodstream infections the most common. The remaining isolates were obtained from patient screening and considered to be colonizing the patients. Most (77.6%) CPEn infection isolates were healthcare associated. The predicted in-hospital mortality rate of patients with CPEn infections was 32.9%. We extende

SUBMITTER: Wu S 

PROVIDER: S-EPMC12403762 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature