Insights on pathoadaptation of sequential <i>Pseudomonas aeruginosa</i> isolates to the urinary tract.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen responsible for 10% of nosocomial urinary tract infections (UTIs). Its large genome and adaptability enable it to cause a wide variety of infections, from respiratory disorders in cystic fibrosis patients to recurrent UTIs. While genomic and phenotypic adaptations of P. aeruginosa have been well-studied in respiratory infections, few studies have investigated pathoadaptation in recurrent UTIs. Here, we investigated the impact of genomic alterations of sequential urinary isolates collected from three patients on phenotypic responses to environmental stresses, virulence, and motility. In addition, to gain insight on adaptive mechanisms of P. aeruginosa in urine, proteomic analyses were conducted using pooled human urine

SUBMITTER: Martin-Duval C 

PROVIDER: S-EPMC12403851 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature