Antidermatophytic activity of Curcuma longa against Trichophyton spp.: compound identification and molecular docking to lanosterol 14α-demethylase.

ABSTRACT: The increasing incidence of dermatophytic infections and rising resistance to conventional antifungal agents necessitates the exploration of alternative therapies. This study investigates the antifungal potential of Curcuma longa rhizome extract against dermatophytes, particularly Trichophyton species, through a combination of in vitro and in silico techniques. The methanolic extract of Curcuma longa was evaluated for its antifungal efficacy using the disc diffusion method against Trichophyton mentagrophytes, Trichophyton indotineae, and Trichophyton interdigitale. The extract demonstrated significant antifungal activity, with inhibition zones ranging from 10 to 25 mm. Comparative analysis with fluconazole revealed that Curcuma longa extract was effective even against fluconazole-resistant

SUBMITTER: Rahman ABZN 

PROVIDER: S-EPMC12403855 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature