<i>Lactobacillus gasseri</i> CECT 30648 shows probiotic characteristics and colonizes the vagina of healthy women after oral administration.

ABSTRACT: Vaginal dysbiosis is linked to recurrent infections and reproductive complications. Probiotics may restore vaginal microbiota, but there is modest evidence to support vaginal colonization after oral administration. This work aimed to screen a vaginal lactobacilli collection (n = 45) and assess vaginal colonization of selected candidates. Lactobacillus gasseri CECT 30648 (Lg) and Lactobacillus crispatus CECT 30647 (Lc) showed excellent in vitro attributes, including antagonism against 10 urogenital pathogens, resistance to gastrointestinal tract and vaginal environment-including high concentrations of biogenic amines-and adhesion to vaginal epithelium. Forty-eight healthy women (18-45 years old) were randomly allocated to consume daily a capsule containing Lg (10

SUBMITTER: Perez M 

PROVIDER: S-EPMC12403894 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature