Gut microbiota alterations modulate high-fat diet-induced precocious puberty.

ABSTRACT: The link between gut microbiota and precocious puberty has garnered increasing attention; however, the underlying mechanisms remain poorly understood, and most existing studies are cross-sectional, making it difficult to capture the longitudinal changes in gut microbiota throughout precocious puberty. Here, female rats were fed high-fat diets supplemented with antibiotics to establish a model of precocious puberty with gut microbiota perturbation. Gut microbiota dynamics were characterized based on stool samples collected at postnatal day (PND) 21, 25, 29, and 33. Serum metabolomic profiles on PND 33 were analyzed to investigate the potential mechanisms by which gut microbiota may influence precocious puberty. We found that alterations in gut microbiota alleviated high-fat diet-induced pre

SUBMITTER: Wu N 

PROVIDER: S-EPMC12403903 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature