Increased plasma ceramide levels are associated with arterial stiffness and vascular ageing: a cross-sectional study.

ABSTRACT:

Background

Cardiovascular (CV) events pose a substantial threat to human health. Plasma ceramides have been shown to exhibit predictive value for CV events; however, its correlation with arterial stiffness had yet to be fully elucidated. This study aimed to explore the associations of plasma ceramide levels and their ratios with arterial stiffness.

Methods

This retrospective study involved participants whose ceramide levels were measured and whose arterial stiffness was assessed. Multivariate regression was used to assess the association between plasma ceramides and arterial stiffness. Restricted cubic spline (RCS) analysis was used to assess the correlation between plasma ceramide levels and arterial stiffness. Receiver operating characteristic (ROC) curves were generated t

SUBMITTER: Ren J 

PROVIDER: S-EPMC12403930 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature