Spatiotemporal subtypes of brain and spinal cord atrophy in neuromyelitis optica spectrum disorders and multiple sclerosis.

ABSTRACT:

Background

Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) are autoimmune demyelinating diseases with overlapping clinical features but distinct patterns of brain and spinal cord atrophy. The precise atrophy subtypes specific to each disease remain elusive. This study aimed to identify shared and distinct atrophy subtypes in NMOSD and MS, using neuroimaging to explore their clinical significance and potential implications for tailored treatment strategies.

Methods

Clinical and MRI data of 278 AQP4 + NMOSD and 391 MS patients were retrospectively and prospectively collected, alongside 1,065 healthy controls. 3D T1-weighted image derived structural measurements were used in a Subtype and Stage Inference model, to identify distinct brain and spinal c

SUBMITTER: Zhuo Z 

PROVIDER: S-EPMC12403954 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature