Platelet-rich plasma (PRP) and the future of male fertility: a path forward for personalized and regenerative therapies.

ABSTRACT:

Background

Platelet-rich plasma (PRP) and its subtype, plasma rich in growth factors (PRGF), are autologous blood-derived products that have garnered increasing attention as personalized therapeutic tools in the field of male fertility. This systematic review aims to evaluate the current in vitro and in vivo evidence regarding the potential applications of platelet-derived products in various domains of male reproductive health, including in vitro spermatogenesis, sperm preservation, treatment of male infertility, mitigation of testicular toxicity, and management of testicular torsion/detorsion (T/D) injury.

Strategy

This review was conducted in accordance with PRISMA guidelines and was prospectively registered in PROSPERO. A comprehensive and language-unrestricted search wa

SUBMITTER: Moradian SA 

PROVIDER: S-EPMC12403957 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature