Plasma proteomics identifies molecular subtypes in sepsis.

ABSTRACT:

Background

The heterogeneity of sepsis represents a significant challenge to the development of personalized sepsis therapies. Sepsis subtyping has therefore emerged as an important approach to this problem, but its impact on clinical practice was limited due to insufficient molecular insights. Modern proteomics techniques allow the identification of subtypes and provide molecular and mechanistical insights. In this study, we analyzed a prospective multi-center sepsis cohort using plasma proteomics to describe and characterize sepsis plasma proteome subtypes.

Methods

Plasma samples were collected from 333 patients at days 1 and 4 of sepsis and analyzed using liquid chromatography coupled to tandem mass spectrometry. Plasma proteome subtypes were identified using K-means clus

SUBMITTER: Bracht T 

PROVIDER: S-EPMC12403962 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature