Multi-omics analysis reveals host-microbe interactions driving divergent energy allocation strategies in Tibetan sheep under cold-season feeding regimes.

ABSTRACT:

Background

As an indigenous livestock species on the Tibetan Plateau, Tibetan sheep exhibit remarkable adaptability to low temperatures and nutrient-scarce environments. During the cold season, Tibetan sheep are typically managed under two feeding regimes: barn feeding (BF) and traditional grazing (TG). However, the molecular mechanisms underlying their adaptation to these distinct management strategies remain unclear. This study aimed to investigate the adaptive strategies of rumen function in Tibetan sheep to cold-season feeding regimes by integrating analyses of rumen morphology, microbiome, metabolome, and transcriptome. Twelve healthy Tibetan sheep with similar body weights were assigned into two groups (BF vs. TG). At the end of the experiment, rumen tissues were subjected to

SUBMITTER: Wang X 

PROVIDER: S-EPMC12403966 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature